
What is Apogen® Microalgae Protein Extract?
FEBICO extracts Apogen®, a Microalgae Protein
FEBICO extracts Apogen®, a Microalgae Protein
Apogen® is a trademarked nutritional ingredient developed and owned by FEBICO. It is used across a system of products formulated with specific microalgae protein extracts and is designed to support normal physiological function and energy metabolism, based on nutritional and preclinical research.
Apogen® is a patented nutritional ingredient concentrated and purified from a proprietary strain of Spirulina (FEM-101). It contains a complex profile of naturally occurring bioactive components, including allophycocyanin (APC), C-phycocyanin (CPC), spirulina growth factors, sulfated polysaccharides, peptides, nucleic acids, amino acids, and trace elements.
Apogen® is intended for use as a dietary and functional food ingredient, supporting overall wellness and the body’s natural regulatory systems. It is not a pharmaceutical drug and is not intended to diagnose, treat, cure, or prevent any disease.
Natural Spirulina FEM-101
Apogen® Microalgae Protein Extract is extracted from FEBICO's self-cultivated Spirulina FEM-101 microalgae strand. It is extracted through a patented extraction method, and can maintain all the beneficial active ingredients.
Apogen® Extracts
Apogen® extracted from an unique strand of spirulina will display a very beautiful blue color under normal lighting conditions. However, it will display a very unique luminous pink under LED lights due to the activities of the extract.
Apogen Microalgae Protein Powder
Apogen® Microalgae Protein Powder is a special combination of the protein combinations between the Spirulina FEM-101 cells and is uniquely different to ordinary spirulina. It is considered an important nutrition amongst microalgae, and displays a beautiful blue color.
How does Apogen® work?
Apogen® does not directly inactivate or kill viruses.Instead, findings from laboratory and preclinical studies suggest that Apogen® may help support normal cellular defense mechanisms by influencing interactions between host cells and external biological stressors, including viruses.
Bioactive Components in Apogen®:Phycobiliproteins
Phycobiliproteins are known for their antioxidant properties and have been shown in preclinical studies to support cellular responses involved in viral interaction, primarily through antioxidant and cell-protective mechanisms.
Sulfated Polysaccharides
Sulfated polysaccharides have been widely studied for their immunomodulatory activities and, in experimental models, have demonstrated the ability to support host defense mechanisms associated with viral challenges.
How does Apogen work?
Based on laboratory and preclinical research, Apogen® has been shown to support normal cellular function during viral exposure by helping maintain cellular integrity and modulating host defense responses. These supportive mechanisms focus on the host cell environment, rather than directly targeting or inactivating viruses.
Apogen® Applications
Apogen® is a water-soluble microalgae protein extract derived from natural Spirulina. It is produced under controlled conditions and is suitable for use as a nutritional ingredient in various delivery formats, including capsules, tablets, granules, solutions, powders, and chewable forms.Preclinical and formulation studies suggest that Apogen® may help support oral mucosal integrity by forming a temporary protective layer on the mucosal surface. This barrier-supporting property may help reduce external stressors, including viral exposure, and contributes to overall immune and mucosal health support.
As a daily nutritional supplement, Apogen® is available in multiple dosage forms to meet different consumer preferences.As a food ingredient, Apogen® can be incorporated into applications such as yogurt, juice, milk, ice cream, chewing gum, jelly, and confectionery products, depending on formulation needs.As a functional ingredient, Apogen® may also be supplied for customized formulations in regulated product development settings, subject to applicable local regulations.
Scientific Background and Research
Apogen® has been evaluated in peer-reviewed scientific publications and patented research, including studies published in the Journal of Medical Virology (70:119–125, 2003). These studies investigated the interaction between spirulina-derived proteins and host cells under experimental viral challenge conditions.The findings from these studies suggest that Apogen® may help support host defense mechanisms at the cellular level in experimental models.
Clinical studies investigated the use of oral Apogen® lozenges as an add-on treatment for patients with mild or moderate COVID-19 symptoms. The clinical research, conducted in collaboration with Taipei Medical University and Taipei Municipal Wan Fang Hospital, specifically tracked patients' recovery and post-infection effects.
The main finding related to post-infection syndrome (Long COVID) was:
- Reduction of Symptoms: Patients who were given the patented microalgae extract lozenges showed a significant reduction in long COVID symptoms 14 days after recovery (p-value < 0.01).
- Improved Quality of Life: This reduction in symptoms, including fatigue, led to a noticeable improvement in quality of life.
- Reduced Fatigue: The data confirmed that continuous intake of the patented microalgae extract lozenge was effective in decreasing symptoms of Long COVID syndrome and reducing fatigue.
Summary Characteristics of Apogen®
Apogen® is a 100% natural, spirulina-derived nutritional ingredient produced through quality-controlled manufacturing processes that ensure heavy metal monitoring and the absence of artificial colorants or preservatives. As a high-purity microalgae protein composition, Apogen® is associated with supporting the body’s natural defenses and maintaining immune balance during various viral challenges. Preclinical studies and experimental models suggest that its active components are involved in supporting the host's cellular protection and antioxidant activity. By contributing to normal immune regulation and overall wellness, this nutrient-dense extract serves as a specialized supplement to support the body's resilience and physiological stability.
1. Apogen® US Patent (US6346408)
2. Phycocyanin's capability to suppress enterovirus results was published in the Journal of Medical Viorlogu 2003 70:119-125
3. Apogen® Taiwan Patent (TW patent I 272947)
4. Apogen® Taiwan Patent (TW patent I 240631)
5. Apogen® Taiwan Patent (TW patent I 295688)
6. Apogen® Childrens granule was awarded with the innovation award from the Health Food Society of Taiwan.
7. Apogen® Probiotics granule was awarded with the innovation product award.
Source Reference
- Hsin-Yu Sung, Chun-Nan Lee, Detection of G1 and G9 rotavirus neutralizing antibodies using reassortant viruses and Study of in vivo anti-rotavirus activity of Apogen, an ex-tract of the microalga Spirulina platensis, 2013
- Yi-Hsiang Chen, Gi-Kung Chang, Shu-Ming Kuo, Sheng-Yu Huang, I-Chen Hu, Yu-Lun Lo, Shin-Ru Shih, Well-tolerated Spirulina extract inhibits influenza virus replication and reduces virus-induced mortality
- Shin-Ru Shih, Kun-Nan Tsai, Yi-Shuane Li, Chuang-Chun Chueh, Err-Cheng Chan, 04 March 2003, Inhibition of enterovirus 71-induced apoptosis by allophycocyanin isolated from a blue-green alga spirulina platensis, J. Med. Virol. 70:119–125, 2003. Pages 119-125
- Chun-Ting Cheng, Chun-Nan Lee, Study of antiviral activity of Apogen, an extract of the microalga Spirulina platensis, 2003, P43
- P. D. Karkos, S. C. Leong, C. D. Karkos, N. Sivaji, and D. A. Assimakopoulos, Spirulina in Clinical Practice: Evidence-Based Human Applications, 2011
Apogen® is classified as a nutritional ingredient and is not a pharmaceutical drug. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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